No Usb Discovery And Cd Change Detection Auto Insert?

Working on xp box, wouldn't backup data from qbpro directly to cd, uninstalled nero, realplayer and other extraneous items, rebooted and wala! No problem, cd writing wizard popped up after backup, did probably 10 backups. She also mentioned that her accountant couldnt get her flashdrive to install anymore. I plugged in usb device. No sweat, popped right up. Today she called, same problem, have to shut machine down completely to resolve it now, windows restart won't fix it. (which sadly, I realize was the case yesterday) She was atttempting to make multiple backup cd's, so she checked burn same again. It comes up with insert writeable cd. Doesn't recognise swap, after exiting cd wizard one time, it did pop up with the contents of the cd, but only one time. Also figured out that if I insert usb device after restart, it recognises it correctly, but then get write error (insert writeable cd) when attempting to do a a backup. If I start doing backups, can do them fine, utnil trying to write same file to another cd. Have found many referneces to autoinsert errors in the registry etc. but auto insert appears to be working after restart. Am confident complete reinstall will fix the problem.