Change Proxy Settings Or Try Resetting Local Connection Setting

i used advanced vista optimiser to give my laptop a good clean out as i do every week. but this time when i went to log on the diagnostic comes and says either change proxy settings or try resetting local connection setting. i tried resetting many a time which as done no good. web address bar states where its going but the diag box comes on again.so in the mean time while this is all going on a new tab keeps on opening by its self and saying the same thing,this started to happen before i cleaned my l.p but it was just redirecting to a blank page.

that is why i did the clean.anyhow resetting the lan did not work so i reset the internet expolorer in the tools on the bar. which as worked but the same thing is still happening with the tab ,but now its redirecting to all the freebiee sites and it will not stop. i have spyware-adware-trojan software on my l.p and still no good it did pick up 3 infections which it sorted out, its driving me f*&^%*ng nuts:mad::mad: