Apply UAC Restrictions To An Additional Folder?

This may seem like a strange thing to do, but today's SSD article reminded me of my desire to find out if this is possible - I have an unusual requirement that discourages me from even going the "small ssd as boot drive, large hdd for other things" route, unless I can find a way to do this. I do QA work for a distributor of downloadable games, so I like to be able to install the entire catalog (150+ GB), and put them into folders under "C:Program Files (x86)", so that I'll be able to see whether the UAC will cause problems for them (I install most of my other programs outside Program Files). Thus, to use ssd+hdd, I would need a way to apply the same restrictions to a folder on the hdd (and preferably also have any virtualized files directed to the hdd as well, but that's less critical).