USB Mouse Stops Responding Until Restart

My USB mouse has been disconnecting on my for months now, and I thought it was a problem with the mouse, however, I bought a new one the other day and the problem persists. It goes like this: 5 minutes or two hours or more hours in, my mouse will stop responding. Sometimes there's a lead up of intermittent disconnecting and reconnecting, sometimes there isn't. Either way, it eventually goes down for good and will NOT respond until I restart the computer. The Keyboard and the speakers which are also powered by USB are fine, just the mouse is dead.

If I try to switch ports, the mouse is still dead. If I use a port on my usb hub, it's still dead. I'd searched and tried several fixes, like going to Advanced Power Options and disabling Selective Suspend. I've gone to Device Manager and unchecked: "Allow the computer to turn off this device to save power." Nothing has worked. For what it's worth, I think it happens quicker when I'm playing a video game like Sims 3 or Skyrim. That or it's just more annoying so it sticks in my mind more. Both of the mice I've been trying use the HID-Compliant Mouse driver.

Logitech M510 (Wireless)
And
J660D Dell mouse that come with the computer (Corded)

System
Manufacturer Dell Inc.
Model XPS 8300
Total amount of system memory 12.0 GB RAM
System type 64-bit operating system
Number of processor cores 4

Storage
Total size of hard disk(s) 1850 GB
Disk partition (C 870 GB Free (1850 GB Total)
Media drive (D CD/DVD
Media drive (K CD/DVD

Graphics
Display adapter type NVIDIA GeForce GTX 560 Ti
Total available graphics memory 4095 MB
Dedicated graphics memory 1024 MB
Dedicated system memory 0 MB
Shared system memory 3071 MB
Display adapter driver version 8.17.12.9573
Primary monitor resolution 1920x1080
DirectX version DirectX 10