Laptop AND Desktop Are Infected

other day my desktop came down with something. windows has slowed to a crawl.. if i click on the start menu, 2 minutes later it will pop up. if i click on a program (firefox, for example) it will never open and the whole comp will just sit there frozen forever.. if i leave it for a few hours like that, firefox will have finally opened.. once in firefox.. it seems i can move about a bit quicker.. but its still unbearably slow. in (advanced) processes menu everything is fine, and the cpu level seems to be where it should be, nothing using up all the cpu that i can see.. after a restart (by holdiong the power button down), i can move around normally for about 1-2 minutes then it basically freezes up again. next i went on my laptop to look up names of processes (to see what they do) and 10 minutes later, the laptop is doing the SAME THING.also, my friends computer seems to be doing the same thing. I was sending some emails with attachemtns to him recently. (eMail worm?)

i can only get them to function in safe mode, and the weird thing is.. bit-defender says its clean of viruses, and ive used search&destroy, spysweeper, ad-aware, and nod32 to clean out most stuff.. but nothing seems to help. also, it seems that S&D will find a bunch of stuff and clear it out fine, and if I run the check again immediately after it finds the same bad stuff again. this is only in regular mode, in safe mode it finds nothing.