Computer Freezes Unless Running In SAFE Mode?

I have a Toshiba laptop running Win 7 (64bit). Lately the computer freezes up in less than five minutes if running in normal mode, leaving only hard-boot option. When restarting, I go to "Safe with Networking" mode, and everything seems to run fine, even internet. I have repeatedly run scans from: Malwarebytes; SuperAntiSpyware; SpyBot; Windows Defender; CCleaner; Periform FixCleaner; TDSSKiller, and probably another half dozen. I have reset the Hosts file, and recovered to a reset point established back in December, before the current problems began. Nothing has solved the problem (any threats found in the various scans were removed, but that had no effect on the current problem). I suspect, from the scan results, that the problem is not malware. I think there may be a corrupt or damaged file or process somewhere in the system. The OS is factory installed, and the laptop did not come with a Windows disk. What's the best way to clean this up