Chrome.exe No Disk Error

Every time I open a new tab, or even a new instance of Google Chrome, or sometimes even just clicking a link on a page in Chrome, Chrome freezes, and sometimes other apps freeze too, and after somewhere between 10 seconds and 60 seconds, an error message occurs.The error message is titled "chrome.exe - No Disk" The message body says "There is no disk in the drive. Please insert a disk into drive DeviceHarddisk5DR5.It presents three clickable options: Cancel, Try Again, and Continue.If I click Try again or Continue, I can usually (99% of the time) move on without further problems, but the big problem is the delay between when the offending activity occurs (opening a new tab or instance of Chrome, or clicking a link on a page in Chrome) and when the error message shows up.

Here's my machine data:

Tech Support Guy System Info Utility version 1.0.0.1
OS Version: Microsoft Windows 7 Professional , 64 bit
Processor: Intel(R) Core(TM) i7 CPU 930 @ 2.80GHz, Intel64 Family 6 Model 26 Stepping 5
Processor Count: 8
RAM: 12278 Mb
Graphics Card: NVIDIA GeForce 9800 GT , 1024 Mb
Hard Drives: C: Total - 76316 MB, Free - 10092 MB; D: Total - 111099 MB, Free - 109455 MB; E: Total - 842765 MB, Free - 610592 MB; M: Total - 953634 MB, Free - 779505 MB;
Motherboard: ASUSTeK Computer INC., P6T, Rev 1.xx, 103986630001623
Antivirus: None