Beaten But Not Quitting

Keeps Quitting In Certain Directory

I recently installed a 1Tb Hitachi Hard Drive. As far as I can tell, it is working fine. I have filled half of it with with the contents of 3 smaller drives and all the content copied over flawlessly. However, now, when I go to one paricular directory on the drive, I get a RUN32DLL error which causes windows explorere to shut down and restart, srambling my quick launch, task bar, systray and desktop to unrecognizable condition which I have to spend forever straightening out!

I don't know that the drive has anything to do with it or if it's a coincidence that it just started happening after I installed the drive. what could be causing this? I already did a virus scan with Avast and Spybot. Nothing there. I tried a scandisk on reboot, no problems found. What gives?